Liphatsa tsa rona tsa lefutso, le lintlha tse ling, re fumana hore na caffeine e re ama joang
Ho utloahala ha caffeine ho bolela hore na kankere e ngata e na le likarolo life. Batho ba nang le ts'oaetso e sa tloaelehang ea caffeine ba ka ba le matšoao a bohlokoa - a kang ho tšoenyeha, ho thothomela, ho otloa ke hlooho, ho otloa ke pelo, le ho hlobaela - ka mor'a ho fepa lijo tse nyenyane tse nang le caffeine, batho ba nang le kutloisiso ea caffeine ba lokela ho leka ho qoba ka ho feletseng caffeine.
Motho o na le bothata ba ho ba le caffeine e thehiloe ke lintlha tse 'maloa tse kenyeletsang lilemo le thobalano, empa ntho e kholo ka ho fetisisa ke liphatsa tsa lefutso. Ho basali, ho utloahala ha caffeine ho boetse ho etsoa ka matla haholo ka tšebeliso ea lithibela-mafu, le ka ho ima.
Kamoo Caffeine e sebelisoang ke Metabolized kateng
Caffeine e kenngoa ka potlako ho tsoa maleng ho ea mali, 'me e tšela tšitiso ea mali-boko ka bobebe bokong. E boetse e tšela ka bolokolohi placenta ho basali ba bakhachane.
Bokong, caffeine e ikamahanya le li-receptor, e leng ho thibela adenosine ho li khomarela. Hobane adenosine e romela boko hore ke nako ea ho robala, ho thibela li-receptor tse nang le adenosine li na le phello ea ho hlahisa.
Caffeine e na le methapoli ka sebete ka enzyme e bitsoang CYP1A2 ho theophylline, paraxanthine le theobromine, ebe e ntšoa ke liphio ka metsing. Bophelo ba halofo ea cafeine e tloaelehile ka lihora tse 4 ho isa ho tse 6, tseo ka tloaelo li leng le nako e kae e ka re amang.
Ke'ng e Amang Kotsi ea K'hafeine?
Ho ba le kutloisiso ho caffeine haholo ho thehiloe ke mosebetsi oa enzyme ea CYP1A2 sebeteng. Ha e ntse e sebetsa ka matla CYP1A2, ha re nahane haholo ka caffeine. Lintlha tse 'maloa li ama mosebetsi oa CYP1A2:
- lilemo: CYP1A2 mosebetsi o fokotseha ka lilemo, kahoo batho ba hōlileng ba atisa ho ba le kankere haholo ho caffeine
- ho kopanela liphate: basali ba atisa ho ba le mesebetsi e tlase ea CYP1A2 ho feta banna.
- Tšebeliso ea meriana ea meriana le bokhachane: li-estrogen li thibela mosebetsi oa CYP1A2, 'me ho ba le kutloisiso ea caffeine ho eketsa
- Lihlahisoa tsa liphatsa tsa lefutso: Hona joale ho khetholloa liphatsa tse ngata tsa liphatsa tsa lefutso tse amanang le mosebetsi oa CYP1A2.
Matšoao a rona a Genese le Caffeine
Ho hlahlojoa ha liphatsa tsa lefutso ho senotse likarolo tse tharo tse tloaelehileng tse nang le kutloisiso ea caffeine e amanang le liphatsa tsa rona tsa lefutso:
- E phekola ka Caffeine : Batho bana ba na le mosebetsi o tlase oa CYP1A2. Ba tla ba le karabo e matla esita le ho ba le lik'hiloana tse nyenyane tsa caffeine, 'me ka tloaelo ba tla ba le li-jitters le ho hlobaela.
- Kelello ea tlhaho ea Caffeine : Ena ke batho ba bangata haholo. Ba ka ja 400 mg ya cafeine ka letsatsi ntle le litla-morao tse bohloko.
- Ho ba le bothata ba ho ba le caffeine e tlaase : Batho bana ba na le mosebetsi o phahameng haholo oa CYP1A2, 'me hangata ha ba na phello leha e le efe ho tloha ka ho ja caffeine. Batho ba tsubang hangata ba ekelitse mosebetsi oa CYP1A2.
Le hoja ho hlahlojoa ha liphatsa tsa lefutso ho ka arola boemo ba hau ba ho ba le bothata ba caffeine, ho ba le teko ea tlhahlobo ha hoa hlokahala hore u tsebe - bonyane ka kakaretso u bua - ebang o na le bothata ba ho ba le caffeine kapa che. 'Me haeba u joalo, ho ka etsahala hore ha ho motho ea lokelang ho u bolella hore u fokotse.
Boimana le ho ba le kutloisiso ea cafeine
Ho ba le bokhachane ka botšepehi ho eketsa kutloisiso ea caffeine. Bophelo ba halofo ea caffeine ka bakhachane e atisa ho feta nako e telele ho feta basali ba saimana - hangata ho fihlela lihora tse 16. Ho feta moo, caffeine e kenella ka maling a malinyane - 'me lesea le na le karolo e nyenyane haholo ea CYP1A2. Le hoja liphello tse tebileng tse kotsi ho lesea le bakoang ke ho ja ha caffeine ha 'mè ha le e-s'o ngoloe, taba ena ha e e-s'o ithute haholo. Ka kakaretso, bakhachane ba lokela ho leka ho fokotsa kapa ho qoba caffeine.
> Mehloli:
> Cornelis MC, Byrne EM, Esko T, le al. Consortium ea Kofi le Caffeine Genetics. Boitsebiso bo hlalosang batho ka bophara bo hlahisa li-loci tse tšeletseng tse amanang le tloaelo ea kofi. Molecular Psychiatry 20, 647-656 (May 2015) | doi: 10.1038 / mp.2014.107
> Grant DM, Tang BK, Kalow W. Phapang ea caffeine metabolism. Clinical Pharmacology & Therapeutics, 33 (5), 591-602, 1983.
> Grosso LM, Bracken MB. Caffeine metabolism, liphatsa tsa lefutso, le liphello tsa perinatal: tlhahlobo ea lintlha tsa tlhahlobo ea tlhahlobo ea tlhahlobo nakong ea bokhachane. Ann Epidemiol 2005; 15: 460.