Thuso Bakeng sa Mafu a Neurological
Sebōpuoa ke e 'ngoe ea lipatlisiso tse sebelisoang ka ho fetisisa le tse sebelisoang ka ho fetisisa ho ntlafatsa mesifa le kholo. E tsebahala har'a baatlelete, baetsi ba 'mele le ba batlang ho ntlafatsa katleho ea lipapali. Sebōpuoa se bontšoa e le se seng sa bopaki bo molemo ka ho fetisisa bo amohelehang bo amohelehang lijong tsa lipapali . Le hoja ho bontšoa ho ntlafatsa ntlafatso ea mesifa, moetsi o boetse o reretsoe ho thusa batho ba nang le mafu a kelello.
Lipatlisiso tsa nako e telele li tsoela pele ho tšehetsa mochine o bapalang karolo ea bohlokoa tsamaisong ea methapo ea methapo (CNS). Ho bonahala eka supplementation ea creatine e ka fokotsa matšoao a mafu a ho qetela a kang a Alzheimer's, Parkinson, ALS le Huntington.
Creatine ke eng?
Sebōpuoa ke ntho ea tlhaho e entsoeng ka amino acid, glycine, arginine le methionine. Li-amino acids ke liprotheine tse hahang. Sebōpeho se hlahisoa sebeteng, liphio le lik'hamphani 'me se lebisitsoe haholo-holo linthong tsa mesifa. Litho tse fokolang li abuoa ka mali a rona ho bokong le likarolong tse ling.
Sebōpuoa se boetse se fumanoa mehlaleng ea liprotheine tsa liphoofolo joaloka nama le tlhapi ho phaella ho hlahisoa 'meleng.
E Sebetsa Joang Meleng ea Rōna
Sebōpuoa se ikarabella ho fana ka matla ho lisele tse ka har'a 'mele le ho boloka mesebetsi ea rona ea selefouno e lekana. E hlaha ka tlhaho 'me e boetse e fanoa ka ho ja lijo tse itseng le li-supplement.
Ha pōpo e kene kapa e etsoa ke 'mele, e feta ka mokhoa oa lik'hemik'hale' me e bōpa phosphate . Molek'hule ena e boloketsoeng e fana ka matla a potlakileng ho lisele tse 'nileng tsa tlosoa nakong ea boiteko bo matla ba' mele kapa chefo.
Sebōpuoa sa phosphate se boetse se tsejoa e le phosphocreatine (PCr). Sebōpeho se ntlafatsa boikoetliso bo sebetsang ka ho eketsa PCr kapa ATP (adenosine tri-phosphate). ATP ke mohloli o mong oa matla o sebelisoang nakong ea matla a potlakileng a matla joaloka sprinting kapa lifting.
Mofuta oa polokelo ea creatine (phosphocreatine) ke mohloli o ka sehloohong oa matla a fanang ka matla a fokolang a matla a holimo. Baatlelete ba tlatseletsa le creatine hobane ba khona ho fana ka matla le ho eketsa boholo ba mesifa.
Sebōpuoa se fetohile feela ho feta ts'ebeliso ea lipapali tsa baatlelete . Lipatlisiso li bontšitse hore ho na le bohlokoa ba bohlokoa ho phekola mafu a seoa. Ke matla a phekolo ea ho lebisa tlhokomelo ea matla a lisele tsa cellular e ka fokotsa matšoao a mafu a kelello ho bakuli.
Pōpo le Lipatlisiso tsa Mahlale
Ho ea ka lipatlisiso tse phatlalalitsoeng ho Journal of Nelomolecular Medicine, moetsi o bontšoa hore ke phekolo e sebetsang bakeng sa lefu la Huntington le la Parkinson. Ho bonahala eka creatine e ntlafatsa matla a lisele tsa cellular liphateng tsa boko tse fokotsang matšoao a menahano ea methapo ea pelo.
Lipatlisiso mabapi le litlhaloso tse ling tsa nako e telele li ile tsa etsoa hape. Bakuli ba lilemo li mashome a tšeletseng ba ile ba hlahlojoa ka lilemo tse peli 'me ba fuoa 4g / d ea creatine kapa placebo. Sepheo sa bona e ne e le ho netefatsa hore mosebetsi oa boithaopo o nepahetse ha o ntse o tlatsetsa le mohloli oa mafu bakeng sa mafu a methapo. Sebōpeho se ne se bontšoa hore se lumelloa hantle ho bakuli ba hōlileng ba nang le lefu la Parkinson. Liphio kapa ts'ebetso ea renal li ne li lula ka har'a meeli e tloaelehileng 'me liphello tse mpe feela tsa lehlakoreng le leng li bonahala eka ke linako tse ling tse halefisitsoeng ke mpa.
Liphuputso tse ling li bonts'a tlatsetso ea khalase ho ntlafatsa mehopolo ea kelello le ho hopola batho ba phelang hantle le bakuli ba mafu a Alzheimer's pele.
Lipatlisiso tsa sebōpeho li ile tsa etsoa ho bakuli ba nang le mafu a Lou Gehring. Ts'oaetso ena ea kelello e fokolisa li-neurons tsa tsamaiso ea methapo e ka hare. Sebōpeho se ne se bontšoa hore se ka fana ka phello ea methapo ea pelo.
Ka kakaretso, supplementation ea creatine e bontšoa ho fana ka tšireletso ea methapo ea lisele. Liphuputso tse sa khaotseng li bontša hore creatine e ba moemeli ea sebetsang hantle oa phekolo ea mali. Bakuli ba ntseng ba nka popine ba bile ba ntlafalitse mosebetsi oa motlakase le boleng bo ntlafatsang ba bophelo.
Tšepo bakeng sa mafu a kelello
Ho ka 'na ha e-ba le tšepo bakeng sa ba nang le maloetse a methapo joaloka Parkinson, Alzheimer's, Amyotrophic Lateral Sclerosis (ALS) le Huntington.
Sebōpeho se bonahala se bapala karolo ea bohlokoa ho boloka matla a lisele tsa lisele tsa cellular. Lipatlisiso li bontšitse liphello tse tšepisang ho fokotsa tsoelo-pele ea mafu a mang a methapo.
Ho bonahala eka ho na le pontšo e matla bakeng sa supplementation ea creatine e le mokhoa oa phekolo ea ho phekola mafu a methapo. Litholoana tse ntle li tšehetsa lipatlisiso tse eketsehileng.
Ntho e 'ngoe le e' ngoe ea lefu la kelello e fana ka matla a fapaneng a matla ao ho ka 'nang ha e-ba le molemo kapa ho se ke oa rua molemo ho tlatsetso ea pōpo. Lefu la Alzheimer (AD) ka mohlala le fumanoe ho bontša ntlafatso le tlatsetso ea creatine feela mehatong ea pele. Hamorao, phekolo ea AD e ne e sa atlehe ka lebaka la li-deposit tse fumanoang bokong.
Litlhahlobo tsa lingaka tsa Parkinson's (PD) li senola bokhoni ba ho eketsa palo ea PD. Sebōpeho se bonahala se na le melemo ea nako e telele bakeng sa batho ba nang le PD.
Amyotrophic Lateral Sclerosis (ALS) ka bomalimabe 'me ka tsela e tsoanang le lefu la Alzheimer (AD) ha aa ka a arabela ka katleho ho tlatsetsa tlatsetso.
Li-supplementation tsa "Creatine" li bontšitse bokhoni bo bongata ba ho phekola lefu la Huntington (HD). Lipatlisiso li bonts'a bopaki bo matla bo tšehetsang ho bōpa hore e be setsebi se sebetsang sa lefu lena. Sebōpeho se ka qetella se ntlafatsa le ho eketsa boleng ba bophelo ho batho ba nang le HD.
> Mehloli:
> Andreas Bender et al., Long-term creatine supplementation e sireletsehile ho bakuli ba nang le lefu la Parkinson, Phuputso ea phepo e nepahetseng , 2008
> Journal ea Biomedicine le Biotechnology, Laebrari ea Sechaba ea Meriana ea United States, Mekhatlo ea Sechaba ea Bophelo, The Creatine Kinase / Creatine Ho Kopana le Maloetse a Alzheimer: CK Inactivation, APP-CK Complexes, le Depoits Focal Creatine, Tanja S. Bürklen et al., 2006
> Molao-motheo oa American Academy of Neurology, neurology.org, PRECREST: Teko ea bobeli ea thibelo le ea tlhaho ea tlhaho ea sebōpeho se kotsi kotsing ea Huntington, Herminia D. Rosas, MD et al., 3/11/14
> Official Journal of the American Academy of Neurology, neurology.org, teko ea kliniki e sa tloaelehang, e se nang bokooa, e se nang thuso ea créatin le minocycline matšoao a pele a Parkinson, Dr. Bernard Ravina, 3/14/06
> Laebrari ea Sechaba ea Meriana ea US, Mekhatlo ea Sechaba ea Bophelo, Lihlahisoa Tse Nyenyane tsa Likokoana-hloko, Karolo ea phetoho ea likokoana-hloko, Klein AM, Ferrante RJ, 2007